Department of Neuropathology and the Second Clinic of Internal Medicine, Kommunehospitalet, Aarhus University School of Medicine, Aarhus, Denmark.
Diabetologia. 1966 Apr;1(3-4):233-41. doi: 10.1007/BF01257917.
A study of the clinical observations and the neuropathological findings in the brain of 16 juvenile diabetics dying of diabetic angiopathy after many years of diabetes is presented. A characteristic histological pattern was observed in all the cases consisting of diffuse degenerative abnormalities of the brain tissue, often with severe pseudocalcinosis or with atrophy of the dentate nucleus, demyelinisation of the cranial nerves, fibrosis of the leptomeninges and angiopathy. The degenerative changes were so pronounced that a dual pathogenesis seems likely; viz. an ischemia caused by the angiopathy and a primary diabetic abnormality of the brain tissue. The clinical symptoms of cerebral disease varied from insignificant to pronounced. A correlation was found between the symptoms and the number of areas of softening in the brain. The histological pattern differs from that seen in other clinical conditions and justifies the term diabetic encephalopathy.
本文报告了 16 例死于糖尿病性血管病的青少年糖尿病患者的临床观察和脑尸检病理结果。所有病例均呈现出一种特征性的组织学模式，包括脑组织弥漫性退行性病变，常伴有严重的假性钙质沉着或齿状核萎缩、颅神经脱髓鞘、软脑膜纤维化和血管病变。退行性改变非常明显，因此可能存在双重发病机制，即血管病变引起的缺血和脑组织的原发性糖尿病异常。脑部疾病的临床症状从无症状到明显不等。症状与脑软化灶数量之间存在相关性。这种组织学模式与其他临床情况不同，因此有理由使用“糖尿病性脑病”这一术语。
