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使用具有大于 1000nm 荧光发射波长的小分子有机纳米粒子进行生物成像。

Biological imaging using nanoparticles of small organic molecules with fluorescence emission at wavelengths longer than 1000 nm.

机构信息

Department of Chemistry, Stanford University, Stanford, CA 94305 (USA).

出版信息

Angew Chem Int Ed Engl. 2013 Dec 2;52(49):13002-6. doi: 10.1002/anie.201307346. Epub 2013 Oct 31.

DOI:10.1002/anie.201307346
PMID:24174264
Abstract

Embedded in a polymer: A hydrophobic organic molecule that fluoresces in the near-infrared II (NIR-II) region was made water-soluble and biocompatible by its embedment in a polymer nanoparticle, which was then coated with hydrophilic poly(ethylene glycol) chains. The resulting nanoparticles exhibit bright fluorescence in the NIR-II window and high photostability in aqueous media and were used for in vivo imaging in mice.

摘要

嵌入聚合物中

通过将疏水性有机分子嵌入聚合物纳米颗粒中，使其水溶性和生物相容性得到改善，该纳米颗粒随后用亲水性聚乙二醇链进行涂层。所得纳米颗粒在近红外二区（NIR-II）窗口显示出明亮的荧光，在水介质中具有高的光稳定性，并用于小鼠体内成像。

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