Fuxe K, Siegel R A, Andersson K, Eneroth P, Mascagni F, Agnati L F
Acta Physiol Scand. 1985 Nov;125(3):437-43. doi: 10.1111/j.1748-1716.1985.tb07740.x.
By means of a Walton Horizontal Smoking Machine, male rats were exposed to the smoke from I-4 cigarettes burned in a continuous fashion. Cholecystokinin (CCK) and substance P levels (determined by means of radio-immunoassay) were measured in discrete hypothalamic and preoptic regions. Acute continuous exposure to cigarette smoke induced increases in CCK levels in the paraventricular hypothalamic region as well as decreases in CCK levels in the median eminence. Furthermore, this treatment resulted in decreased CCK and substance P levels in the medial preoptic region. The results have been interpreted to indicate that CCK and substance P containing neuronal systems can be regulated by cholinergic nicotine-like receptors.
通过一台沃尔顿卧式吸烟机，雄性大鼠被暴露于连续燃烧4支香烟所产生的烟雾中。采用放射免疫分析法测定了下丘脑和视前区不同部位的胆囊收缩素（CCK）和P物质水平。急性持续暴露于香烟烟雾导致下丘脑室旁核区域CCK水平升高，同时正中隆起部位CCK水平降低。此外，这种处理还导致视前内侧区CCK和P物质水平下降。这些结果被解释为表明含CCK和P物质的神经元系统可受胆碱能尼古丁样受体调控。
