应激性心肌病患者血浆血清素水平升高的首个证据。
First evidence of increased plasma serotonin levels in Tako-Tsubo cardiomyopathy.
作者信息
Rouzaud Laborde C, Delmas C, Mialet-Perez J, Pizzinat N, Biendel-Picquet C, Boudou N, Dumonteil N, Spreux-Varoquaux O, Carrié D, Galinier M, Parini A, Lairez O
机构信息
Inserm, Metabolic and Cardiovascular Disease Institute of Rangueil, 31432 Toulouse, France ; Paul Sabatier University, 31062 Toulouse, France ; Department of Pharmacy, University Hospital Center, 31059 Toulouse, France.
出版信息
Biomed Res Int. 2013;2013:847069. doi: 10.1155/2013/847069. Epub 2013 Sep 23.
BACKGROUND
There is no data about the serotonergic activity during the acute phase of Tako-Tsubo Cardiomyopathy (TTC). The objective of our study was to investigate evidence of serotonin release from patients with TTC in comparison with patients with ST elevation myocardial infarction (STEMI) and healthy control subjects (HCS).
METHODS AND RESULTS
Plasma serotonin levels in 14 consecutive patients with TTC were compared with those in 14 patients with STEMI and 14 HCS. Plasma serotonin levels at admission were markedly higher in patients with TTC and STEMI as compared to HCS (3.9 ± 4.6, P = 0.02 versus control; 5.7 ± 5.6, P = 0.001 versus control; and 1 ± 0.4 ng/mL, resp.). There was no difference in serotonin levels between patients with TTC and those with STEMI (P = 0.33).
CONCLUSION
This finding suggests that serotonin could participate to the pathophysiology of TTC.
背景
关于应激性心肌病（TTC）急性期的血清素能活性尚无数据。我们研究的目的是调查与ST段抬高型心肌梗死（STEMI）患者和健康对照者（HCS）相比，TTC患者血清素释放的证据。
方法与结果
将14例连续的TTC患者的血浆血清素水平与14例STEMI患者和14例HCS的血浆血清素水平进行比较。与HCS相比，TTC和STEMI患者入院时的血浆血清素水平明显更高（分别为3.9±4.6，P = 0.02对比对照组；5.7±5.6，P = 0.001对比对照组；以及1±0.4 ng/mL）。TTC患者和STEMI患者之间的血清素水平没有差异（P = 0.33）。
结论
这一发现表明血清素可能参与了TTC的病理生理过程。
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