Chard T, Rice A, Kitau M J, Hird V, Grudzinskas J G, Nysenbaum A M
Br J Obstet Gynaecol. 1986 Jan;93(1):36-8. doi: 10.1111/j.1471-0528.1986.tb07810.x.
Elevated maternal levels of alphafetoprotein (AFP) in midtrimester are believed by some to be a useful screening test for premature labour, low birthweight and low birthweight for gestation. In a prospective study on 887 randomly selected pregnant women we found that although there was an association between low birthweight and elevated AFP, the test would miss five out of every six cases of low birthweight and there would be nine false-positives for every case correctly identified. The test is not therefore sufficiently predictive of low birthweight to be of value as a screening test for this condition.
一些人认为，孕中期孕妇甲胎蛋白（AFP）水平升高是早产、低出生体重和小于胎龄儿低出生体重的有效筛查指标。在一项对887名随机选择的孕妇进行的前瞻性研究中，我们发现，虽然低出生体重与AFP升高之间存在关联，但该检测每六例低出生体重病例中会漏诊五例，且每正确识别一例就会有九例假阳性。因此，该检测对低出生体重的预测性不足，不能作为这种情况的筛查检测。
