[各种抗有丝分裂剂在人体中诱导的染色体畸变的特征分析]
[Characterization of chromosomal aberrations induced in man by various antimitotic agents].
作者信息
Turchini M F, Geneix A, Perissel B, Malet P, Turchini J P
出版信息
C R Seances Soc Biol Fil. 1985;179(3):331-9.
PMID:2417673
Abstract
Six antitumoral drugs were tested in human lymphocytes cultures. Our observations pointed out specific abnormalities beside more usual chromosomal aberrations. These lesions are mainly telomeric and chromatidic fusions, chromomerisations and despiralizations. We present an interpretation of these abnormalities.
摘要
在人类淋巴细胞培养物中对六种抗肿瘤药物进行了测试。我们的观察指出，除了更常见的染色体畸变外，还有特定的异常情况。这些病变主要是端粒和染色单体融合、染色粒形成和解螺旋。我们对这些异常情况进行了解释。
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