Dept of Medicine, National University Health System, Singapore.
Eur Respir J. 2014 Mar;43(3):852-62. doi: 10.1183/09031936.00081713. Epub 2013 Oct 31.
The effect of employing severity scores to identify severe community-acquired pneumonia (SCAP) cases for early aggressive resuscitation is unknown. Optimising pre-intensive care unit (ICU) care may improve outcomes in patients at risk of SCAP. We conducted a before-and-after study of patients classified into control and intervention groups (January 2004 to December 2007 and January 2008 to December 2010, respectively). Our intervention was two-pronged, using the 2007 Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) minor criteria to identify SCAP for aggressive emergency department resuscitation. Patients with SCAP, defined as those with three or more IDSA/ATS minor criteria, were targeted. Differences in mortality, triage and compliance with emergency department resuscitation were compared between the groups. The hospital mortality rate was lower in the intervention versus the control group (5.7% versus 23.8%, p<0.001). On multivariate analysis, the intervention group was associated with lower mortality (OR 0.24, 95% CI 0.09-0.67). ICU admission rates decreased from 52.9% to 38.6% (p=0.008) and inappropriately delayed ICU admissions decreased from 32.0% to 14.8% (p<0.001). There was increased compliance with the aggressive resuscitation protocol after the intervention. A combined intervention, using a pneumonia score to identify those at risk of SCAP early and an aggressive pre-ICU resuscitation protocol may reduce mortality and ICU admissions.
采用严重程度评分来识别严重社区获得性肺炎(SCAP)病例以进行早期积极复苏的效果尚不清楚。优化重症监护病房(ICU)前的护理可能会改善有发生 SCAP 风险的患者的结局。我们进行了一项病例前后对照研究,将患者分为对照组和干预组(分别为 2004 年 1 月至 2007 年 12 月和 2008 年 1 月至 2010 年 12 月)。我们的干预措施有两部分,一是使用 2007 年美国传染病学会(IDSA)/美国胸科学会(ATS)的次要标准来识别需要积极急诊复苏的 SCAP;二是针对具有三个或更多 IDSA/ATS 次要标准的 SCAP 患者进行治疗。比较两组之间的死亡率、分诊和对急诊复苏的依从性。干预组的死亡率低于对照组(5.7%比 23.8%,p<0.001)。多变量分析显示,干预组与较低的死亡率相关(OR 0.24,95%CI 0.09-0.67)。ICU 入院率从 52.9%降至 38.6%(p=0.008),不适当延迟 ICU 入院率从 32.0%降至 14.8%(p<0.001)。干预后,对积极复苏方案的依从性增加。采用肺炎评分来早期识别有发生 SCAP 风险的患者,并采用积极的 ICU 前复苏方案,可能会降低死亡率和 ICU 入院率。