Division of Respiratory and Critical Care Medicine, Dept of Medicine, National University Hospital, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074.
Eur Respir J. 2010 Oct;36(4):826-33. doi: 10.1183/09031936.00154209. Epub 2010 Feb 25.
The primary objective of the present study was to evaluate the effect on hospital mortality of a delay in intensive care unit (ICU) admission for severe community-acquired pneumonia (CAP). The secondary objectives were to assess if such delays were associated with treatment variations by the emergency department (ED) and deterioration in the general wards, and to evaluate the prognostic ability of the Infectious Disease Society of America (IDSA)/American Thoracic Society (ATS) minor criteria. We retrospectively compared patients who were admitted straight from the ED to the ICU (direct group, n = 54) and those who were first admitted from the ED to the general wards before ICU transfer (delayed group, n = 49), over 2.5 yrs. Even after excluding patients who required mechanical ventilation and/or vasopressors at the ED, delayed ICU admission was an independent predictor of hospital mortality (OR 9.61). The delayed group received fewer fluid boluses in the ED and rapidly deteriorated in the general wards. The presence of ≥3 IDSA/ATS minor criteria was associated with increased mortality in the delayed group. In conclusion, prompt recognition of severe CAP using the IDSA/ATS minor criteria, followed by aggressive management at the ED and direct ICU admission, are all crucial toward improving outcomes.
本研究的主要目的是评估重症社区获得性肺炎(CAP)患者 ICU 入住延迟对住院死亡率的影响。次要目的是评估 ICU 延迟是否与急诊科(ED)治疗方案的变化以及普通病房病情恶化有关,并评估美国传染病学会(IDSA)/美国胸科学会(ATS)次要标准的预后能力。我们回顾性比较了直接从 ED 入住 ICU 的患者(直接组,n = 54)和先从 ED 入住普通病房再转入 ICU 的患者(延迟组,n = 49),观察时间为 2.5 年以上。即使排除 ED 需要机械通气和/或血管加压素的患者,ICU 延迟入住仍然是住院死亡率的独立预测因素(OR 9.61)。延迟组在 ED 接受的液体冲击量较少,且在普通病房病情迅速恶化。延迟组中,存在≥3 项 IDSA/ATS 次要标准与死亡率增加相关。总之,使用 IDSA/ATS 次要标准及时识别重症 CAP,随后在 ED 积极治疗并直接入住 ICU,对于改善预后至关重要。