Biophysics Group and Donner Laboratory, University of California, Berkeley, California.
J Membr Biol. 1971 Dec;6(4):329-52. doi: 10.1007/BF02116578.
A fundamental approach to calculate the diffusion of ions through membranes is introduced. The membran eis considered as a heterogeneous structure with molecules that can have a selective affinity for a certain class of diffusing ions. To diffuse through a membrane an ion must become associated with, or dissolved into, at least one component of that membrane. Diffusion is produced by thermal jumps from one molecular site to another. It is assumed that the electric field can change the binding properties between ions and membrane molecules. The kinetics of the conductances are calculated from the chemical kinetic theory. The calculations are compared to the squid axon data and the unknown parameters are adjusted to fit the data curves. The results are very satisfactory. The calculated activation energies correspond to the measuredQ 10 in the squid axon. The calculated and measured action potentials are quite similar.
介绍了一种计算离子通过膜扩散的基本方法。该膜被认为是一种具有分子的不均匀结构，这些分子对特定类别的扩散离子具有选择性亲和力。为了通过膜扩散，离子必须与膜的至少一种成分结合或溶解。扩散是通过热跳跃从一个分子位置到另一个分子位置产生的。假设电场可以改变离子和膜分子之间的结合特性。电导率的动力学是根据化学动力学理论计算的。将计算结果与鱿鱼轴突数据进行比较，并调整未知参数以拟合数据曲线。结果非常令人满意。计算出的激活能与鱿鱼轴突中测量的 Q10 相对应。计算出的和测量出的动作电位非常相似。
