Department of Genetics, University College of Swansea, SA2 8PP, Singleton Park, Swansea, UK.
Curr Genet. 1984 Jan;8(1):69-76. doi: 10.1007/BF00405434.
Ethidium bromide was found to inhibit nuclear and mitochondrial DNA synthesis during meiosis which resulted in the inhibition of meiotic gene conversion and sporulation and was also lethal. Protection from the effects of ethidium bromide on meiotic gene conversion and survival was found to coincide with DNA synthesis, but it is possible that protection from sporulation inhibition occurs only later in meiosis.
溴化乙锭被发现会在减数分裂过程中抑制核和线粒体 DNA 的合成,从而抑制减数分裂基因转换和孢子形成,并且具有致死性。发现免受溴化乙锭对减数分裂基因转换和存活的影响与 DNA 合成一致,但也有可能免受孢子形成抑制的保护仅在减数分裂后期才发生。