组织中ω-3多不饱和脂肪酸水平的升高可预防病理性早产。
Increased tissue levels of omega-3 polyunsaturated fatty acids prevents pathological preterm birth.
作者信息
Yamashita Aki, Kawana Kei, Tomio Kensuke, Taguchi Ayumi, Isobe Yosuke, Iwamoto Ryo, Masuda Koji, Furuya Hitomi, Nagamatsu Takeshi, Nagasaka Kazunori, Arimoto Takahide, Oda Katsutoshi, Wada-Hiraike Osamu, Yamashita Takahiro, Taketani Yuji, Kang Jing X, Kozuma Shiro, Arai Hiroyuki, Arita Makoto, Osuga Yutaka, Fujii Tomoyuki
机构信息
Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
出版信息
Sci Rep. 2013 Nov 1;3:3113. doi: 10.1038/srep03113.
Omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid (EPA) have anti-inflammatory effects. Preterm birth is an important problem in modern obstetrics and one of the main causes is an inflammation. We here showed that abundance of omega-3 fatty acids reduced the incidence of preterm birth induced by LPS with fat-1 mice, capable of converting omega-6 to omega-3 fatty acids. We also indicated that the gene expression of IL-6 and IL-1β in uteruses and the number of cervical infiltrating macrophages were reduced in fat-1 mice. The analyses of lipid metabolomics showed the high level of 18-hydroxyeicosapentaenoate in fat-1 mice, which was derived from EPA and was metabolized to anti-inflammatory product named resolvin E3 (RvE3). We finally showed that the administration of RvE3 to LPS-exposed pregnant wild type mice lowered the incidence of preterm birth. Our data suggest that RvE3 could be a potential new therapeutic for the prevention of preterm birth.
ω-3多不饱和脂肪酸，如二十碳五烯酸（EPA）具有抗炎作用。早产是现代产科中的一个重要问题，其主要原因之一是炎症。我们在此表明，ω-3脂肪酸的丰富含量降低了脂多糖诱导的早产发生率，这是通过能够将ω-6脂肪酸转化为ω-3脂肪酸的fat-1小鼠实现的。我们还指出，fat-1小鼠子宫中白细胞介素-6（IL-6）和白细胞介素-1β（IL-1β）的基因表达以及宫颈浸润巨噬细胞的数量减少。脂质代谢组学分析显示，fat-1小鼠中18-羟基二十碳五烯酸水平较高，其源自EPA，并代谢为名为消退素E3（RvE3）的抗炎产物。我们最终表明，向暴露于脂多糖的野生型妊娠小鼠施用RvE3可降低早产发生率。我们的数据表明，RvE3可能是预防早产的一种潜在新疗法。
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