Beenen N, Büttner U, Lange H W
Electroencephalogr Clin Neurophysiol. 1986 Feb;63(2):119-27. doi: 10.1016/0013-4694(86)90005-2.
Eye movements were studied with EOG in a large number of Huntington's disease (HD) patients (N = 48) and their offspring (subjects at risk, N = 97). The following oculomotor paradigms were investigated: horizontal and vertical saccades of different sizes (10-80 degrees), smooth pursuit eye movements, optokinetic and vestibular nystagmus. It was found that 75% of the HD patients had pathologically slow saccades. This number rose to 87% if other oculomotor deficits were included. Thus a small, but definite number of HD patients had normal eye movements. This included patients with disease durations of more than 14 years. A comparison with the results of clinical and evoked potential studies on these patients showed that they were clinically only mildly affected but did not form a different group of HD patients. Subjects at risk had statistically (P less than 0.01) slower horizontal saccades (average 427 deg/sec) than the controls (455 deg/sec). For 11% of the subjects at risk horizontal saccade velocity was pathological and altogether 22% had some oculomotor deficits. Subjects with pathological slow horizontal saccades also had a high incidence (64%) of pathological evoked potentials. Thus, subjects with pathological slow horizontal saccades can be considered to have a high risk of developing the clinical symptoms of HD.
采用眼电图（EOG）对大量亨廷顿舞蹈病（HD）患者（N = 48）及其后代（有患病风险的受试者，N = 97）的眼球运动进行了研究。研究了以下眼球运动模式：不同大小（10 - 80度）的水平和垂直扫视、平稳跟踪眼球运动、视动性眼震和前庭性眼震。结果发现，75%的HD患者扫视速度病理性减慢。如果将其他眼球运动缺陷也包括在内，这一比例升至87%。因此，有一小部分但确切数量的HD患者眼球运动正常。这包括病程超过14年的患者。将这些患者的临床和诱发电位研究结果与之比较发现，他们在临床上仅受到轻度影响，但并未形成一个不同的HD患者群体。有患病风险的受试者水平扫视速度在统计学上（P < 0.01）比对照组（455度/秒）慢（平均427度/秒）。11%有患病风险的受试者水平扫视速度病理性减慢，总体上22%有一些眼球运动缺陷。水平扫视速度病理性减慢的受试者诱发电位异常的发生率也很高（64%）。因此，水平扫视速度病理性减慢的受试者可被认为有很高的风险出现HD的临床症状。
