Bredenberg C E, Nieman G F, Paskanik A M, Hart A K
J Appl Physiol (1985). 1986 Jan;60(1):253-9. doi: 10.1152/jappl.1986.60.1.253.
Pulmonary edema was induced in dogs by an aerosol of detergent dioctyl sodium sulfosuccinate. The permeability of the pulmonary microvascular membrane was assessed by cannulating an afferent tracheobronchial lymphatic and comparing the lymph-to-plasma total protein concentration (CL/CP) during high lymph flows induced by increasing left atrial (LA) pressure after detergent aerosol. Base-line CL/CP of 0.69 +/- 0.02 fell to 0.55 +/- 0.03 with increased LA pressure alone. CL/CP fell to 0.47 +/- 0.02 when LA pressure was increased following detergent, 0.51 +/- 0.04 following an aerosol of the vehicle in which the detergent was dissolved, and 0.73 +/- 0.10 following intravenous alloxan. In additional animals protein concentration of the airway edema fluid was compared with that of plasma. The ration of protein concentration of airway fluid to plasma was 0.63 +/- 0.08 following detergent aerosol, 0.64 +/- 0.10 following increased LA pressure, and 0.94 +/- 0.09 following administration of alloxan. These data indicate no major increase in pulmonary microvascular permeability following detergent aerosol and support the concept that pulmonary edema is the consequence of reduced interstitial perimicrovascular hydrostatic pressure caused by increased alveolar surface tension.
通过向狗雾化吸入去污剂磺基琥珀酸二辛酯钠来诱发肺水肿。通过插入一条传入气管支气管淋巴管，并比较在雾化吸入去污剂后通过增加左心房（LA）压力诱导的高淋巴流量期间淋巴液与血浆的总蛋白浓度（CL/CP），来评估肺微血管膜的通透性。仅增加LA压力时，基线CL/CP为0.69±0.02降至0.55±0.03。在使用去污剂后增加LA压力时，CL/CP降至0.47±0.02，在雾化吸入溶解去污剂的赋形剂后为0.51±0.04，在静脉注射四氧嘧啶后为0.73±0.10。在另外的动物中，比较了气道水肿液与血浆的蛋白浓度。雾化吸入去污剂后气道液与血浆的蛋白浓度比为0.63±0.08，增加LA压力后为0.64±0.10，注射四氧嘧啶后为0.94±0.09。这些数据表明雾化吸入去污剂后肺微血管通透性没有明显增加，并支持肺水肿是由肺泡表面张力增加导致的间质微血管周围静水压力降低的结果这一概念。
