Department of Chemistry, University of Houston , Houston, Texas 77204-5003, United States.
Org Lett. 2013 Nov 15;15(22):5842-5. doi: 10.1021/ol402904d. Epub 2013 Nov 1.
A method for direct, auxiliary-assisted alkoxylation and phenoxylation of β-sp(2) C-H bonds of benzoic acid derivatives and γ-sp(2) C-H bonds of amine derivatives is reported. The reaction employs (CuOH)2CO3 catalyst, air as an oxidant, phenol or alcohol coupling partner, DMF, pyridine, or DMPU solvent, and K2CO3, tetramethylguanidine, or K3PO4 base at 70-130 °C.
报道了一种直接、辅助辅助的苯甲酸盐衍生物的β-sp(2)C-H 键和胺衍生物的γ-sp(2)C-H 键的烷氧基化和苯氧基化方法。该反应采用(CuOH)2CO3 催化剂、空气作为氧化剂、苯酚或醇偶联剂、DMF、吡啶或 DMPU 溶剂以及 K2CO3、四甲基胍或 K3PO4 碱,在 70-130°C 下进行。