Takemura Noriaki, Kuninobu Yoichiro, Kanai Motomu
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Biomol Chem. 2014 Apr 28;12(16):2528-32. doi: 10.1039/c4ob00215f.
We achieved intra- and intermolecular C(sp(3))-H alkoxylation of benzylic positions of heteroaromatic compounds using CuBrn (n = 1, 2)/5,6-dimethylphenanthroline (or 4,7-dimethoxyphenanthroline) and ((t)BuO)2 as a catalyst and an oxidant, respectively. The reaction proceeded at both terminal and internal benzylic positions of the alkyl groups. The intramolecular alkoxylation was performed on a gram scale.
我们使用CuBrn（n = 1, 2）/5,6 - 二甲基菲咯啉（或4,7 - 二甲氧基菲咯啉）和二叔丁基过氧化物（(t)BuO）2分别作为催化剂和氧化剂，实现了杂芳族化合物苄基位置的分子内和分子间C(sp(3))-H烷氧基化反应。该反应在烷基的末端和内部苄基位置均能进行。分子内烷氧基化反应已在克级规模上进行。
