Jia Zhen-Sheng, Yue Qiang, Li Ya, Xu Xue-Tao, Zhang Kun, Shi Bing-Feng
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong, 529020, China.
Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang, 310027, China.
Beilstein J Org Chem. 2021 Sep 28;17:2488-2495. doi: 10.3762/bjoc.17.165. eCollection 2021.
A copper-catalyzed mono-selective C-H amination of ferrocenes assisted by 8-aminoquinoline is presented here. A range of amines, including bioactive molecules, were successfully installed to the -position of ferrocene amides with high efficiency under mild conditions. A range of functionalized ferrocenes were compatible to give the aminated products in moderate to good yields. The gram-scale reaction was smoothly conducted and the directing group could be removed easily under basic conditions.
本文介绍了一种在8-氨基喹啉辅助下铜催化的二茂铁单选择性C-H胺化反应。在温和条件下，一系列胺，包括生物活性分子，成功地以高效率安装到二茂铁酰胺的α-位。一系列功能化二茂铁具有兼容性，能以中等至良好的产率得到胺化产物。克级反应顺利进行，导向基团在碱性条件下可轻松去除。
