Pinnas J L, Lindberg R E, Chen T M, Meinke G C
J Allergy Clin Immunol. 1986 Feb;77(2):364-70. doi: 10.1016/s0091-6749(86)80119-1.
In the southern and western sections of the United States, bites from the reduviid bug, commonly known as the kissing bug, genus Triatoma, may induce serious life-threatening allergic reactions. This study was undertaken to identify the allergens responsible for patient sensitization and to determine the extent of cross-reactivity of these allergens. The Triatoma spp. most commonly encountered in California and Arizona, T. protracta and T. rubida, were obtained, maintained in the laboratory, and dissected to prepare extracts for testing. Extracts were prepared from T. protracta and T. rubida for study by RAST, lymphocyte transformation, leukocyte histamine release, and RAST inhibition. Sera and cells were collected from patients who had generalized reactions to Triatoma bites. Our results indicate that T. protracta and T. rubida antigens to which patients are sensitized are present in extracts that contain saliva and that human responses are specific for T. protracta or T. rubida, i.e., allergic cross-reactivity could not be demonstrated.
在美国南部和西部，锥蝽（俗称接吻虫，锥猎蝽属）叮咬可能引发严重的、危及生命的过敏反应。本研究旨在确定导致患者致敏的过敏原，并确定这些过敏原的交叉反应程度。获取了在加利福尼亚州和亚利桑那州最常见的锥蝽物种——长红锥蝽和红带锥蝽，在实验室饲养并解剖，以制备提取物用于检测。从长红锥蝽和红带锥蝽制备提取物，通过放射变应原吸附试验（RAST）、淋巴细胞转化、白细胞组胺释放和RAST抑制进行研究。从对锥蝽叮咬有全身性反应的患者中采集血清和细胞。我们的结果表明，患者致敏的长红锥蝽和红带锥蝽抗原存在于含有唾液的提取物中，并且人体反应对长红锥蝽或红带锥蝽具有特异性，即未显示出过敏交叉反应。
