Taurel Anne-Frieda, Guatteo Raphaël, Lehebel Anne, Joly Alain, Beaudeau François
INRA, UMR1300 Biologie, Epidémiologie et Analyse de Risque en santé animale, BP 40706, F-44307 Nantes, France; LUNAM Université, Oniris, Ecole nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique, UMR BioEpAR, F-44307 Nantes, France; Union Bretonne des Groupements de Défense Sanitaire, F-56000 Vannes, France.
INRA, UMR1300 Biologie, Epidémiologie et Analyse de Risque en santé animale, BP 40706, F-44307 Nantes, France; LUNAM Université, Oniris, Ecole nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique, UMR BioEpAR, F-44307 Nantes, France.
Comp Immunol Microbiol Infect Dis. 2014 Jan;37(1):1-9. doi: 10.1016/j.cimid.2013.10.002. Epub 2013 Oct 14.
The effectiveness of the vaccination of dairy cows combined or not with antibiotics (i.e. oxytetracycline) to control Coxiella burnetii (Cb) shedding at herd level was investigated in 77 Q fever clinically affected herds. In addition to nulliparous heifers' vaccination, one out of the four following medical strategies was randomly assigned to dairy cows in each herd: vaccination (using a phase I vaccine) alone, vaccination combined with oxytetracycline, oxytetracycline alone or nothing. Their effectiveness to reduce Cb load in quarterly samples of bulk tank milk (BTM) and of pooled milk of primiparous (MP) was assessed through logistic hierarchical models. A significant reduction in Cb load was observed in herds where the vaccination of ≥80% of dairy cows was implemented; whereas the use of antibiotics was uneffective. Our findings support the interest of a whole vaccination strategy and provide evidence for decreasing the use of antibiotics in dairy cattle herds.
在77个临床感染Q热的牛群中，研究了奶牛接种疫苗（联合或不联合抗生素，即土霉素）在畜群水平上控制伯氏考克斯体（Cb）排泄的效果。除了未产小母牛接种疫苗外，每个牛群中的奶牛被随机分配到以下四种医疗策略中的一种：单独接种疫苗（使用I期疫苗）、接种疫苗联合土霉素、单独使用土霉素或不采取任何措施。通过逻辑分层模型评估它们在降低季度散装罐牛奶（BTM）和初产奶牛混合奶（MP）样本中Cb负荷方面的效果。在实施≥80%奶牛接种疫苗的牛群中，观察到Cb负荷显著降低；而使用抗生素则无效。我们的研究结果支持全面接种疫苗策略的益处，并为减少奶牛群中抗生素的使用提供了证据。
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