Huber Niclas, Gundling Natascha, Thurow Maria, Ligges Uwe, Hoedemaker Martina
Clinic for Cattle, University of Veterinary Medicine Hanover, Foundation, Bischofsholer Damm 15, 30173 Hannover, Germany.
Department of Statistics, TU Dortmund University, 44221 Dortmund, Germany.
Animals (Basel). 2024 May 3;14(9):1375. doi: 10.3390/ani14091375.
It was the aim of this study to examine whether the usage of the vaccine COXEVAC (Ceva Santé Animale) could reduce the consumption of antibiotics in Q-fever-positive dairy farms. Additionally, the effects of other herd-level factors on the consumption of antibiotics were investigated. A total of 36 farms with vaccination and 13 farms without vaccination participated in this longitudinal cohort study. In all herds, had been directly or indirectly diagnosed. To compare the treatment frequency of antibiotics between the vaccinated group and the non-vaccinated group, the consumption of antibiotics for each farm was collected using the veterinary documents about the application and delivery of antibiotics. To gather detailed information about herd data, nutrition, milking management, housing, and animal health, the farmers were interviewed with the help of a questionnaire. The results thereof suggest that there might be an association between the vaccination against Q fever and a reduced consumption of antibiotics. Neither herd size nor milk yield level influenced the consumption of antibiotics in the study herds. Type of flooring and udder-cluster disinfection while milking were associated with a lower and higher therapy frequency, respectively. Further studies are necessary to elucidate the cause-effect relationship between vaccination and the consumption of antibiotics.
本研究旨在检验疫苗COXEVAC（塞瓦动物保健公司生产）的使用是否能减少Q热阳性奶牛场的抗生素使用量。此外，还研究了其他畜群水平因素对抗生素使用量的影响。共有36个接种疫苗的农场和13个未接种疫苗的农场参与了这项纵向队列研究。在所有畜群中，均已被直接或间接诊断。为比较接种组和未接种组之间抗生素的治疗频率，利用有关抗生素使用和交付的兽医文件收集了每个农场的抗生素使用量。为收集有关畜群数据、营养、挤奶管理、畜舍和动物健康的详细信息，借助问卷对农民进行了访谈。其结果表明，Q热疫苗接种与抗生素使用量减少之间可能存在关联。畜群规模和产奶量水平均未影响研究畜群中的抗生素使用量。挤奶时的地板类型和乳房组消毒分别与较低和较高的治疗频率相关。有必要进行进一步研究以阐明疫苗接种与抗生素使用之间的因果关系。
