Will H, Salfeld J, Pfaff E, Manso C, Theilmann L, Schaler H
Science. 1986 Feb 7;231(4738):594-6. doi: 10.1126/science.2418501.
Nucleocapsid-pol fusion proteins have been detected by serological screening hepatocellular carcinoma tissues that contain hepatitis B virus (HBV) DNA. The existence of these fusion proteins suggests that HBV may synthesize its reverse transcriptase in a fashion analogous to the way that retroviruses synthesize and process a precursor. The accumulation of HBV reverse transcriptase intermediates in tumorous tissues and not in other tissues may be related to the absence of viral core particles and possibly contributes to tumor development.
通过血清学筛查含有乙型肝炎病毒（HBV）DNA的肝细胞癌组织，已检测到核衣壳-聚合酶融合蛋白。这些融合蛋白的存在表明，HBV可能以类似于逆转录病毒合成和加工前体的方式合成其逆转录酶。HBV逆转录酶中间体在肿瘤组织而非其他组织中的积累可能与病毒核心颗粒的缺失有关，并可能有助于肿瘤的发展。
