Mohammad F K, St Omer V E
Toxicol Lett. 1985 Dec;29(2-3):215-23. doi: 10.1016/0378-4274(85)90044-x.
Pregnant rats were gavaged with a 1:1 mixture of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) at 0 (G0), 50 (G 50) and 100 (G 100) mg/kg per day on gestational days 6-15. Treatment significantly (P less than 0.05) delayed ontogeny of dopamine (DA), but not norepinephrine (NE) levels, in the thalamus-hypothalamus on postnatal day 7; in the pons-medulla on days 7,9 and 15; and in the olfactory lobes on day 9. On day 25, serotonin (5-HT) levels were significantly decreased in the pons-medulla of G 100 rats, whereas 5-hydroxyindoleacetic acid (5-HIAA) levels decreased in the thalamus-hypothalamus and pons-medulla of G 50 and G 100 rats.
在妊娠第6至15天，给怀孕大鼠每日灌胃剂量为0（G0）、50（G50）和100（G100）毫克/千克的2,4-二氯苯氧乙酸（2,4-D）和2,4,5-三氯苯氧乙酸（2,4,5-T）的1:1混合物。在出生后第7天，治疗显著（P<0.05）延迟了丘脑-下丘脑多巴胺（DA）水平的个体发育，但对去甲肾上腺素（NE）水平无影响；在第7、9和15天，脑桥-延髓的DA水平受到影响；在第9天，嗅叶的DA水平受到影响。在第25天，G100组大鼠脑桥-延髓中的血清素（5-HT）水平显著降低，而G50和G100组大鼠丘脑-下丘脑和脑桥-延髓中的5-羟吲哚乙酸（5-HIAA）水平降低。
