成纤维细胞及其“立足之地”。
Fibroblasts and the ground they walk on.
机构信息
Department of Environmental Health, Molecular and Integrative Physiological Sciences, Harvard School of Public Health, Boston, Massachusetts.
出版信息
Physiology (Bethesda). 2013 Nov;28(6):380-90. doi: 10.1152/physiol.00024.2013.
Abstract
Fibroblast migration is essential to normal wound healing and pathological matrix deposition in fibrosis. This review summarizes our understanding of how fibroblasts navigate 2D and 3D extracellular matrices, how this behavior is influenced by the architecture and mechanical properties of the matrix, and how migration is integrated with the other principle functions of fibroblasts, including matrix deposition, contraction, and degradation.
摘要
成纤维细胞迁移对于正常的伤口愈合和纤维化中的病理性基质沉积至关重要。这篇综述总结了我们对成纤维细胞如何在 2D 和 3D 细胞外基质中导航的理解，这种行为如何受到基质的结构和力学特性的影响，以及迁移如何与成纤维细胞的其他主要功能（包括基质沉积、收缩和降解）整合。
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