Sáiz Jorge, Mai Thanh Duc, López María López, Bartolomé Carmen, Hauser Peter C, García-Ruiz Carmen
Department of Chemistry I, Multipurpose Building of Chemistry, University of Alcalá, Ctra. Madrid-Barcelona km 33.600, 28871 Alcalá de Henares, Madrid, Spain; University Institute of Research in Police Sciences (IUICP), University of Alcalá, Ctra. Madrid-Barcelona km 33.600, 28871 Alcalá de Henares, Madrid, Spain.
Sci Justice. 2013 Dec;53(4):409-14. doi: 10.1016/j.scijus.2013.08.001. Epub 2013 Aug 29.
In recent years, scopolamine has become a drug of common use for recreational and predatory purposes and several ways of administration have been devised. A method for the rapid analysis of suspicious samples was developed, using a portable capillary electrophoresis with contactless conductivity detection. The method allows the separation of scopolamine from atropine which has a similar structure and is present along with scopolamine in some samples. The method was demonstrated to be useful for the fast analysis of several types of evidential items which have recently been reported to have been abused with fatal consequences or employed for criminal purposes. An infusion of Datura stramonium L., in which scopolamine and atropine naturally coexist, was analyzed for being frequently consumed for recreational purposes. A spiked moisturizing cream and six spiked alcoholic beverages were also analyzed. In spite of the complexity of the specimens, the sample pre-treatment methods developed were simple and fast.
近年来，东莨菪碱已成为用于娱乐和掠夺目的的常用药物，并且已经设计出几种给药方式。开发了一种使用带非接触式电导检测的便携式毛细管电泳快速分析可疑样品的方法。该方法能够将东莨菪碱与阿托品分离，阿托品结构相似，在一些样品中与东莨菪碱同时存在。该方法被证明可用于快速分析几种类型的证据物品，最近有报道称这些物品被滥用会导致致命后果或被用于犯罪目的。分析了曼陀罗的浸液，其中东莨菪碱和阿托品天然共存，该浸液因娱乐目的而经常被饮用。还分析了加标保湿霜和六种加标酒精饮料。尽管样品复杂，但所开发的样品预处理方法简单且快速。
