Eckstein M, Hurlemann R
Abteilung für Medizinische Psychologie und Soziologie, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Sigmund-Freud-Str. 25, 53105, Bonn, Deutschland.
Nervenarzt. 2013 Nov;84(11):1321-8. doi: 10.1007/s00115-013-3832-6.
Only few substances have achieved such a great prominence in recent years as the hypothalamic neuropeptide oxytocin, which is also widely known as the love hormone. Oxytocin is a potent neuromodulator which can improve social cognitive functions including empathy, trust, cooperation and social learning. However, oxytocin can also promote negative social behavior and increase poor memory and feelings of fear in social situations. Positive data from initial clinical trials give rise to the hope that oxytocin will prove to be a substance which is suitable for targeted treatment of poor social-cognitive behavior in neuropsychiatric diseases. This review article summarizes the most important recent preclinical and clinical human studies and discusses the findings presented with respect to current concepts of personal and contextual influences.
近年来，只有少数物质能像下丘脑神经肽催产素那样备受瞩目，催产素也广为人知，被称为“爱情荷尔蒙”。催产素是一种强大的神经调节剂，能够改善包括同理心、信任、合作和社会学习在内的社会认知功能。然而，催产素也会促进负面社交行为，并增加社交场合中的记忆力减退和恐惧情绪。初步临床试验的积极数据让人们产生了这样的希望：催产素将被证明是一种适合针对性治疗神经精神疾病中社会认知行为不良的物质。这篇综述文章总结了近期最重要的临床前和临床人体研究，并结合个人和情境影响的当前概念对所呈现的研究结果进行了讨论。
