保持静默：染色质对γ疱疹病毒潜伏的控制。
Keeping it quiet: chromatin control of gammaherpesvirus latency.
机构信息
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.
出版信息
Nat Rev Microbiol. 2013 Dec;11(12):863-75. doi: 10.1038/nrmicro3135. Epub 2013 Nov 6.
Abstract
The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) establish long-term latent infections associated with diverse human cancers. Viral oncogenesis depends on the ability of the latent viral genome to persist in host nuclei as episomes that express a restricted yet dynamic pattern of viral genes. Multiple epigenetic events control viral episome generation and maintenance. This Review highlights some of the recent findings on the role of chromatin assembly, histone and DNA modifications, and higher-order chromosome structures that enable gammaherpesviruses to establish stable latent infections that mediate viral pathogenesis.
摘要
人类γ疱疹病毒 EBV（Epstein-Barr 病毒）和 KSHV（卡波西肉瘤相关疱疹病毒）会建立与多种人类癌症相关的长期潜伏感染。病毒致癌依赖于潜伏病毒基因组作为染色体外体在宿主核内持续存在的能力，这些染色体外体表达受限制但具有动态变化的病毒基因模式。多种表观遗传事件控制病毒染色体外体的产生和维持。本综述强调了染色质组装、组蛋白和 DNA 修饰以及高级染色体结构在允许γ疱疹病毒建立稳定潜伏感染以介导病毒发病机制方面的一些最新发现。
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