Kobayashi Nobuyuki, Shimada Kazuya, Ishii Azusa, Osaka Rui, Nishiyama Toshiko, Shigeta Masahiro, Yanagisawa Hiroyuki, Oka Naomi, Kondo Kazuhiro
Department of Virology, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
Department of Public Health & Environmental Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.
iScience. 2024 Feb 10;27(3):109203. doi: 10.1016/j.isci.2024.109203. eCollection 2024 Mar 15.
The heritability of major depressive disorder (MDD) is reportedly 30-50%. However, the genetic basis of its heritability remains unknown. Within SITH-1, a risk factor for MDD in human herpesvirus 6B (HHV-6B), we discovered a gene polymorphism with a large odds ratio for an association with MDD. It was a sequence whose number of repeats was inversely correlated with SITH-1 expression. This number was significantly lower in MDD patients. Rates for 17 or fewer repeats of the sequence were 67.9% for MDD and 28.6% for normal controls, with an odds ratio of 5.28. For patients with 17 or less repeats, the rate for presence of another MDD patient in their families was 47.4%, whereas there were no MDD patients in the families of patients with more than 17 repeats. Since HHV-6B is transmitted primarily mother to child and within families and persists for life, this gene polymorphism could potentially influence heritability of MDD.
据报道，重度抑郁症（MDD）的遗传率为30%-50%。然而，其遗传率的遗传基础仍不清楚。在人类疱疹病毒6B（HHV-6B）中，作为MDD的一个风险因素的SITH-1内，我们发现了一种与MDD关联的比值比很大的基因多态性。它是一个重复序列，其重复次数与SITH-1表达呈负相关。该重复序列的重复次数在MDD患者中显著更低。该序列重复17次及以下的比例在MDD患者中为67.9%，在正常对照中为28.6%，比值比为5.28。对于重复次数为17次及以下的患者，其家族中另一位MDD患者出现的比例为47.4%，而重复次数超过17次的患者家族中没有MDD患者。由于HHV-6B主要通过母婴传播且在家族内传播并终生存在，这种基因多态性可能会影响MDD的遗传率。
