Lieberman Paul M
The Wistar Institute, Philadelphia, PA, 19104, USA.
Curr Top Microbiol Immunol. 2015;390(Pt 1):71-102. doi: 10.1007/978-3-319-22822-8_5.
EBV latent infection is characterized by a highly restricted pattern of viral gene expression. EBV can establish latent infections in multiple different tissue types with remarkable variation and plasticity in viral transcription and replication. During latency, the viral genome persists as a multi-copy episome, a non-integrated-closed circular DNA with nucleosome structure similar to cellular chromosomes. Chromatin assembly and histone modifications contribute to the regulation of viral gene expression, DNA replication, and episome persistence during latency. This review focuses on how EBV latency is regulated by chromatin and its associated processes.
EBV潜伏感染的特征是病毒基因表达模式高度受限。EBV可在多种不同组织类型中建立潜伏感染，病毒转录和复制具有显著的变异性和可塑性。在潜伏期间，病毒基因组作为多拷贝附加体持续存在，这是一种非整合的闭环DNA，其核小体结构类似于细胞染色体。染色质组装和组蛋白修饰有助于在潜伏期间调节病毒基因表达、DNA复制和附加体的持久性。本综述重点关注染色质及其相关过程如何调控EBV潜伏。
