Hacımustafaoğlu Mustafa, Celebi Solmaz, Bozdemir Sefika Elmas, Ozgür Taner, Ozcan Ismail, Güray Atilla, Cakır Deniz
Division of Pediatric Infectious Diseases, Uludağ University Faculty of Medicine, Bursa, Turkey.
Turk J Pediatr. 2013 Mar-Apr;55(2):130-9.
Respiratory syncytial virus (RSV) is the most frequent agent of acute lower respiratory diseases and creates a significant burden of disease in children under 5 years all over the world. RSV causes severe lower respiratory tract infections (LRTI) that require hospitalization, especially in children ≤2 years. The aim of this study was to determine the incidence of RSV in children ≤2 years of age hospitalized for LRTI. Children ≤2 years of age hospitalized for one year for LRTI in the three largest hospitals of Bursa City Center, Turkey were evaluated. These three hospitals comprise 67.5% of all child beds in central Bursa, so this study allows us to evaluate the total disease burden and hospitalization incidence in central Bursa. Nasal swabs of the children were evaluated with RSV Respi- Strip (Coris Bioconcept Organization). A total of 671 children were hospitalized for LRTI, and 254 (37.9%) had at least one hospitalization that was positive for RSV. Of all patients with LRTI, 54.8% (368/671) were hospitalized for acute bronchiolitis, while 45.2% (303/671) were hospitalized for pneumonia. Of patients with acute bronchiolitis or pneumonia, 41% (151/368) and 34% (103/303) were RSV+, respectively. Of RSV+ hospitalized children, 59.5% (151/254) were diagnosed as acute bronchiolitis and 40.5% (103/254) as pneumonia. The annual incidences of hospitalization due to LRTI, acute bronchiolitis and pneumonia were 20.5/1000, 11.2/1000 and 9.3/1000, respectively, in children ≤2 years of age. The annual incidences of hospitalization due to RSV+ LRTI, acute bronchiolitis and pneumonia were found as 7.8/1000, 4.6/1000 and 3.2/1000, respectively, in children ≤2 years of age. More than one-third of all children hospitalized with LRTI (38.3%, n=257) were in the 0-3 months age group. Compared to other age groups, RSV positivity was highest in that age group for acute bronchiolitis (57%), pneumonia (39.5%) and also total children with LRTI (47.9%). RSV is a very important cause of lower respiratory infections in children ≤2 years of age and occurred most frequently in those 0-3 months of age in our study. Since there is no other study assessing the annual hospitalization incidence of RSV+LRTIs in one city in Turkey, our study has unique importance for providing valuable statistical data about RSV+LRTIs.
呼吸道合胞病毒（RSV）是急性下呼吸道疾病最常见的病原体，在全球5岁以下儿童中造成了重大疾病负担。RSV会引发严重的下呼吸道感染（LRTI），需要住院治疗，尤其是2岁及以下儿童。本研究的目的是确定因LRTI住院的2岁及以下儿童中RSV的发病率。对土耳其布尔萨市中心最大的三家医院中因LRTI住院一年的2岁及以下儿童进行了评估。这三家医院占布尔萨市中心所有儿童床位的67.5%，因此本研究使我们能够评估布尔萨市中心的总体疾病负担和住院发病率。用RSV Respi-Strip（Coris Bioconcept组织）对儿童的鼻拭子进行评估。共有671名儿童因LRTI住院，其中254名（37.9%）至少有一次住院检测RSV呈阳性。在所有LRTI患者中，54.8%（368/671）因急性细支气管炎住院，而45.2%（303/671）因肺炎住院。急性细支气管炎或肺炎患者中，RSV阳性分别为41%（151/368）和34%（103/303）。在RSV阳性住院儿童中，59.5%（151/254）被诊断为急性细支气管炎，40.5%（103/254）被诊断为肺炎。2岁及以下儿童因LRTI、急性细支气管炎和肺炎住院的年发病率分别为20.5/1000、11.2/1000和9.3/1000。2岁及以下儿童因RSV阳性LRTI、急性细支气管炎和肺炎住院的年发病率分别为7.8/1000、4.6/1000和3.2/1000。所有因LRTI住院的儿童中，超过三分之一（38.3%，n = 257）在0至3个月年龄组。与其他年龄组相比，该年龄组急性细支气管炎（57%）、肺炎（39.5%）以及所有LRTI儿童（47.9%）的RSV阳性率最高。RSV是2岁及以下儿童下呼吸道感染的一个非常重要的病因，在我们的研究中最常发生在0至3个月大的儿童中。由于没有其他研究评估土耳其一个城市中RSV阳性LRTI的年度住院发病率，我们的研究对于提供有关RSV阳性LRTI的宝贵统计数据具有独特的重要性。
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