Animal Science Department, Utah State University, USA.
Bull Environ Contam Toxicol. 1966 Jan;1(1):6-15. doi: 10.1007/BF01684070.
Selected drugs were tested for effectiveness in reducing dieldrin retention by rats. Female rats were fed diets treated to contain 1 ppm dieldrin. The drugs were administered as feed additives or by i.p. injections. The rats were sacrificed after 10 days of treatment and abdominal adipose tissue was analyzed for dieldrin using electron capture gas chromatography.Heptabarbital (40 and 225 mg/kg rat/day), aminopyrine (75 and 350 mg/kg rat/day), tolbutamide (60 and 290 mg/kg rat/day), and phenylbutazone (90 mg/kg rat/day) were effective as feed additives in reducing tissue dieldrin. Heptabarbital was the most effective and reduced the concentration of tissue dieldrin by 80 per cent at the higher dose level. In comparison, DDT (4 mg/kg rat/day) effected a 72 per cent reduction. A contrast with DDT was also observed in trials with i.p. administration of drugs and DDT. In those trials, the duration of the DDT action was apparently greater than that of the drugs.We suggest that suitable drugs might be used to reduce insecticide accumulation in the tissues of animals and man, and for treatment of individuals after over exposure to insecticides.
选择了一些药物来测试它们对减少大鼠体内狄氏剂残留的效果。雌性大鼠喂食含 1ppm 狄氏剂的饲料。药物作为饲料添加剂或通过腹腔注射给药。治疗 10 天后处死大鼠，用电子俘获气相色谱法分析腹部脂肪组织中的狄氏剂。海托比妥（40 和 225mg/kg 大鼠/天）、氨基比林（75 和 350mg/kg 大鼠/天）、甲苯磺丁脲（60 和 290mg/kg 大鼠/天）和苯丁唑酮（90mg/kg 大鼠/天）作为饲料添加剂在减少组织狄氏剂方面有效。海托比妥的效果最显著，在高剂量水平下将组织狄氏剂的浓度降低了 80%。相比之下，DDT（4mg/kg 大鼠/天）的效果降低了 72%。在腹腔内给予药物和 DDT 的试验中也观察到与 DDT 的对比。在这些试验中，DDT 的作用持续时间显然比药物长。我们建议可以使用合适的药物来减少动物和人体内的杀虫剂积累，并治疗因过度暴露于杀虫剂而受到影响的个体。
Zotero 插件