Minguell J J, Bruzzone M S
Int J Cell Cloning. 1986 Jan;4(1):43-50. doi: 10.1002/stem.5530040105.
The incubation of human bone marrow fibroblasts with hydrocortisone (10(-7) M) produces a time-dependent depletion of hydrocortisone-binding sites. This effect is glucocorticoid-specific, since glucocorticoid agonists cause depletion to the same extent as hydrocortisone. After withdrawal of the hormone from the incubation medium, cells are able to replenish their complement of receptor. The existence of this down-regulation process may represent a protective mechanism against the partial proliferative inhibitory action of glucocorticoids for bone marrow fibroblasts and also a stimulus for differentiation to adipocytes.
将人骨髓成纤维细胞与氢化可的松（10⁻⁷ M）一起孵育会导致氢化可的松结合位点随时间减少。这种效应具有糖皮质激素特异性，因为糖皮质激素激动剂导致的减少程度与氢化可的松相同。从孵育培养基中去除激素后，细胞能够补充其受体。这种下调过程的存在可能代表了一种针对糖皮质激素对骨髓成纤维细胞的部分增殖抑制作用的保护机制，也是向脂肪细胞分化的一种刺激因素。
