Department of Diabetology and Internal Medicine, Pomeranian Medical University in Szczecin, Siedlecka 2, 72-010, Police, Poland,
Inflammation. 2014 Apr;37(2):349-57. doi: 10.1007/s10753-013-9746-4.
The purpose of this study was to assess the concentration of C-reactive protein (CRP) in obese type 2 diabetes mellitus (DM2) patients and its association with macrovascular and microvascular complications. The study group consisted of 80 obese DM2 patients, including 20 macrovascular, 20 microvascular, 20 both macrovascular and microvascular, and 20 with no complications patients. The control group comprised 40 normoglycemic subjects--20 obese and 20 of normal body weight. Highly sensitive CRP and metabolic control parameters were assessed. CRP levels in obese diabetes subgroups and normoglycemic obese were similar and significantly higher than those in nonobese controls. No correlation was found between CRP and diabetes control parameters. There was a strong positive correlation between CRP level and body mass index in all groups. A multivariate analysis showed that DM2 and obesity are independent factors increasing CRP levels. Increased concentration of CRP in obese DM2 patients is related to obesity and diabetes itself. The lack of association between CRP and vascular complications remains unclear.
本研究旨在评估肥胖 2 型糖尿病（DM2）患者 C 反应蛋白（CRP）的浓度及其与大血管和微血管并发症的关系。研究组包括 80 例肥胖 DM2 患者，其中 20 例为大血管并发症，20 例为微血管并发症，20 例为大血管和微血管并发症，20 例无并发症患者。对照组包括 40 例血糖正常的受试者-20 例肥胖和 20 例体重正常。评估了高敏 CRP 和代谢控制参数。肥胖糖尿病亚组和血糖正常肥胖者的 CRP 水平相似，明显高于非肥胖对照组。CRP 与糖尿病控制参数之间无相关性。在所有组中，CRP 水平与体重指数呈强正相关。多元分析表明，DM2 和肥胖是增加 CRP 水平的独立因素。肥胖 DM2 患者 CRP 浓度的增加与肥胖和糖尿病本身有关。CRP 与血管并发症之间缺乏关联仍不清楚。
