Sha Lin, Cao Qian, Lv Li, Fan Guoguang
Department of Radiology, the Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China.
Tumour Biol. 2014 Mar;35(3):2379-82. doi: 10.1007/s13277-013-1314-x. Epub 2013 Nov 7.
Cerebral radiation injury (CRI) is a crucial and common complication of radiotherapy for patients with glioma. In the study, we aimed to investigate the changes in the diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) and the histological changes in the brain tissues of mice models with glioma. After the tumor cell seeding, there was an obvious increase in the proportion of cellular nucleus in the brain tissues of rat models with glioma. There was also an obvious increase in the microvascular density (MVD) in the brain tissues of rat models with glioma. There was a linear correlation between the mean apparent diffusion coefficient value and the proportion of cellular nucleus in the brain tissues of rat models with glioma (P < 0.05). There was also a linear correlation between the maximal relative cerebral volume and MVD count in the brain tissues of rat models with glioma (P < 0.01). Therefore, the changes in the DWI and PWI are related with the histological changes in the brain tissues of glioma, and the finding may help us make a distinction between postoperative recurrent glioma and CRI.
脑辐射损伤（CRI）是胶质瘤患者放疗的一种关键且常见的并发症。在本研究中，我们旨在探究胶质瘤小鼠模型脑组织的扩散加权成像（DWI）和灌注加权成像（PWI）变化以及组织学变化。肿瘤细胞接种后，胶质瘤大鼠模型脑组织中细胞核比例明显增加。胶质瘤大鼠模型脑组织中的微血管密度（MVD）也明显增加。胶质瘤大鼠模型脑组织中平均表观扩散系数值与细胞核比例之间存在线性相关性（P < 0.05）。胶质瘤大鼠模型脑组织中最大相对脑容量与MVD计数之间也存在线性相关性（P < 0.01）。因此，DWI和PWI的变化与胶质瘤脑组织的组织学变化相关，这一发现可能有助于我们区分术后复发性胶质瘤和CRI。
