Department of Pathology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, Neural Stem Cell Institute, Rensselaer, New York 12144, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, St. Jude Children's Research Hospital, Memphis, Tennessee 03105, Department of Neurology, Washington University, St. Louis, Missouri 63110, and Department of Pathology and Laboratory Medicine, University of California, Irvine School of Medicine, Irvine, California 92697.
J Neurosci. 2013 Nov 6;33(45):17553-9. doi: 10.1523/JNEUROSCI.3258-13.2013.
Although universally recognized as the source of cerebrospinal fluid (CSF), the choroid plexus (ChP) has been one of the most understudied tissues in neuroscience. The reasons for this are multiple and varied, including historical perceptions about passive and permissive roles for the ChP, experimental issues, and lack of clinical salience. However, recent work on the ChP and instructive signals in the CSF have sparked new hypotheses about how the ChP and CSF provide unexpected means for regulating nervous system structure and function in health and disease, as well as new ChP-based therapeutic approaches using pluripotent stem cell technology. This minisymposium combines new and established investigators to capture some of the newfound excitement surrounding the ChP-CSF system.
尽管脉络丛（ChP）被普遍认为是脑脊液（CSF）的来源，但它一直是神经科学中研究最少的组织之一。造成这种情况的原因有很多，包括对 ChP 的被动和许可作用的历史观念、实验问题以及缺乏临床意义。然而，最近关于 ChP 和 CSF 中的指示信号的研究工作激发了新的假设，即 ChP 和 CSF 如何为调节健康和疾病中的神经系统结构和功能提供意想不到的手段，以及使用多能干细胞技术的新的基于 ChP 的治疗方法。这个小型研讨会结合了新的和已建立的研究人员，以捕捉围绕 ChP-CSF 系统的一些新发现的兴奋。
