Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
Department of Pathology, Boston Children's Hospital, Boston, MA, USA.
Trends Neurosci. 2021 Nov;44(11):864-875. doi: 10.1016/j.tins.2021.07.002. Epub 2021 Jul 24.
The choroid plexus (ChP), an epithelial bilayer containing a network of mesenchymal, immune, and neuronal cells, forms the blood-cerebrospinal fluid (CSF) barrier (BCSFB). While best recognized for secreting CSF, the ChP is also a hotbed of immune cell activity and can provide circulating peripheral immune cells with passage into the central nervous system (CNS). Here, we review recent studies on ChP immune cells, with a focus on the ontogeny, development, and behaviors of ChP macrophages, the principal resident immune cells of the ChP. We highlight the implications of immune cells for ChP barrier function, CSF cytokines and volume regulation, and their contribution to neurodevelopmental disorders, with possible age-specific features to be elucidated in the future.
脉络丛（ChP）是一种包含间质、免疫和神经元细胞网络的双层上皮组织，形成血脑脊液（CSF）屏障（BCSFB）。虽然脉络丛最被认可的功能是分泌 CSF，但它也是免疫细胞活动的温床，并且可以为循环中的外周免疫细胞提供进入中枢神经系统（CNS）的途径。在这里，我们回顾了最近关于脉络丛免疫细胞的研究，重点介绍了脉络丛巨噬细胞的个体发生、发育和行为，脉络丛巨噬细胞是脉络丛的主要常驻免疫细胞。我们强调了免疫细胞对脉络丛屏障功能、CSF 细胞因子和体积调节的影响，以及它们对神经发育障碍的贡献，未来可能会有特定于年龄的特征需要阐明。
