Molecular basis of peptide activation of the GLP-1 receptor.
作者信息
Miller Laurence J
机构信息
Department of Molecular Pharmacology and Experimental Therapeutics; Mayo Clinic, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA.
出版信息
Mol Metab. 2013 Mar 6;2(2):60-1. doi: 10.1016/j.molmet.2013.02.003. eCollection 2013.
Abstract
摘要
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本文引用的文献
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A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction.GLP-1 受体细胞外结构域上的疏水区位使肽配体定向进行信号转导。
Mol Metab. 2013 Jan 16;2(2):86-91. doi: 10.1016/j.molmet.2013.01.003. eCollection 2013.
2
The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development.分泌素家族 G 蛋白偶联受体肽配体的结构：对受体药理学和药物开发的影响。
Drug Discov Today. 2012 Sep;17(17-18):1006-14. doi: 10.1016/j.drudis.2012.05.005. Epub 2012 May 11.
3
Novel GLP-1 receptor agonists for diabetes.新型 GLP-1 受体激动剂治疗糖尿病。
Expert Opin Investig Drugs. 2012 Jan;21(1):45-57. doi: 10.1517/13543784.2012.638282. Epub 2011 Nov 24.
4
Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist.内酰胺限制提供了关于分泌素受体结合构象的见解，并稳定了受体拮抗剂。
Biochemistry. 2011 Sep 27;50(38):8181-92. doi: 10.1021/bi2008036. Epub 2011 Aug 30.
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Importance of each residue within secretin for receptor binding and biological activity.每个残基在分泌素中对受体结合和生物活性的重要性。
Biochemistry. 2011 Apr 12;50(14):2983-93. doi: 10.1021/bi200133u. Epub 2011 Mar 21.
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Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.胰高血糖素样肽-1 与胰高血糖素样肽-1 受体胞外结构域复合物的晶体结构
J Biol Chem. 2010 Jan 1;285(1):723-30. doi: 10.1074/jbc.M109.033829. Epub 2009 Oct 27.
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Passing the baton in class B GPCRs: peptide hormone activation via helix induction?B类G蛋白偶联受体中的接力传递：通过螺旋诱导实现肽激素激活？
Trends Biochem Sci. 2009 Jun;34(6):303-10. doi: 10.1016/j.tibs.2009.02.004. Epub 2009 May 14.
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Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain.与配体结合的胰高血糖素样肽-1受体胞外域的晶体结构
J Biol Chem. 2008 Apr 25;283(17):11340-7. doi: 10.1074/jbc.M708740200. Epub 2008 Feb 20.
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Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.II类G蛋白偶联促胰液素受体天然配体结合与激活的结构基础
Biochem Soc Trans. 2007 Aug;35(Pt 4):709-12. doi: 10.1042/BST0350709.
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