Tjernlund U, Scheynius A, Asbrink E, Hovmark A
Scand J Immunol. 1986 Mar;23(3):383-8. doi: 10.1111/j.1365-3083.1986.tb01979.x.
Skin biopsies were investigated with two different immunohistochemical techniques, thus revealing HLA-DQ antigens on HLA-DR-expressing keratinocytes in the late skin manifestations of a Borrelia spirochete infection. In the early skin lesions only HLA-DR antigens were present on the keratinocytes. The invariant gamma chain of class II transplantation antigens was observed on keratinocytes in 1:5 of the late cases. Upon penicillin treatment detectable HLA-DR and HLA-DQ antigens disappeared completely from the keratinocytes. Furthermore, the mononuclear cell infiltrates dominated by anti-Leu 1 and anti-Leu 3a-reactive cells and containing many cells with markers for activation (HLA-DR, HLA-DQ, transferrin, and interleukin 2 receptors) diminished markedly. The possibility that the expression of different class II transplantation antigens on keratinocytes might reflect separate functional demands of these cells or an altered immunological reactivity in the host, is discussed. The precise functional role of the temporary expression of the class II antigens on non-lymphoid cells, however, remains an enigma.
采用两种不同的免疫组织化学技术对皮肤活检样本进行研究，结果显示在疏螺旋体感染的晚期皮肤表现中，表达HLA - DR的角质形成细胞上存在HLA - DQ抗原。在早期皮肤病变中，角质形成细胞上仅存在HLA - DR抗原。在1/5的晚期病例中，在角质形成细胞上观察到II类移植抗原的恒定γ链。青霉素治疗后，可检测到的HLA - DR和HLA - DQ抗原从角质形成细胞上完全消失。此外，以抗Leu 1和抗Leu 3a反应性细胞为主且含有许多具有激活标志物（HLA - DR、HLA - DQ、转铁蛋白和白细胞介素2受体）的单核细胞浸润明显减少。文中讨论了角质形成细胞上不同II类移植抗原的表达可能反映这些细胞的不同功能需求或宿主免疫反应改变的可能性。然而，II类抗原在非淋巴细胞上的短暂表达的确切功能作用仍然是个谜。
