Ding A H, Lam K M
Vet Immunol Immunopathol. 1986 Jan;11(1):65-72. doi: 10.1016/0165-2427(86)90088-7.
A non-immune natural killer-type cell population (NK) from 6-to 12-week old chickens was able to kill MSB-1 Marek's disease (MD) tumor cells in vitro; as measured by the 51Cr-release cytotoxicity assay. Removal of T cells, B cells, adherent cells, or any combination of the three populations of cells did not result in diminished levels of cytotoxicity of the remaining spleen cells against MSB-1 cells. The cytotoxicity of chicken NK cells could be rapidly augmented by polyinosinic-polycytidylic acid (poly I:C) and by the Cal 11914 strain of Newcastle disease virus (NDV), but not by the TCND strain of NDV which is not an interferon (IFN) inducer, indicating that IFN play a role in augmentation of the NK activity in chickens.
来自6至12周龄鸡的非免疫自然杀伤细胞群体（NK）能够在体外杀死MSB - 1马立克氏病（MD）肿瘤细胞；这是通过51Cr释放细胞毒性测定法测得的。去除T细胞、B细胞、贴壁细胞或这三种细胞群体的任何组合，都不会导致剩余脾细胞对MSB - 1细胞的细胞毒性水平降低。鸡NK细胞的细胞毒性可被聚肌苷酸 - 聚胞苷酸（poly I:C）和新城疫病毒（NDV）的Cal 11914株迅速增强，但不能被非干扰素（IFN）诱导剂的NDV的TCND株增强，这表明IFN在增强鸡的NK活性中起作用。
