Bakhutashvili V I, Merabishvili D G, Gogitashvili R V, Korsantiia B M, Dzotsenidze L L
Vopr Virusol. 1985 Nov-Dec;30(6):693-7.
The possibility of generating large quantities of highly active interferon from human placenta amniotic membrane (plaferon) has been demonstrated. Plaferon is innocuous and nonreactogenic in experimental models and has an antiviral effect of wide spectrum. The activity is resistant to DNase, RNase, lipase, and stable at pH 2. A polyclonal serum to human leukocyte interferon and monoclonal NK-2 antibody did not inhibit the antiviral activity of plaferon. The level of hormones in plaferon and leukocyte interferon preparations was practically similar. In diploid cultures of human fibroblasts the antiviral condition under the effect of plaferon developed slower than under the effect of leukocyte interferon.
已证实从人胎盘羊膜（胎盘干扰素）中产生大量高活性干扰素的可能性。胎盘干扰素在实验模型中无毒且无反应原性，具有广谱抗病毒作用。其活性对脱氧核糖核酸酶、核糖核酸酶、脂肪酶有抗性，在pH 2时稳定。针对人白细胞干扰素的多克隆血清和单克隆NK - 2抗体均不抑制胎盘干扰素的抗病毒活性。胎盘干扰素制剂和白细胞干扰素制剂中的激素水平实际相似。在人成纤维细胞的二倍体培养中，胎盘干扰素作用下的抗病毒状态比白细胞干扰素作用下发展得慢。
