Zhdanov L V, Schubert K, Orlova T G, Mentkevich L M
Vopr Virusol. 1985 Nov-Dec;30(6):708-10.
The antibacterial JRS vaccine was found to be capable of inducing interferon production in human peripheral blood leukocytes and mouse bone marrow cells. The vaccine induced no interferon in L-929 cells or human diploid M-19 cells. Interferon appeared in the culture fluid within 4-6 hours after induction and reached the maximum levels in 18-24 hours. One-hour contact of the vaccine with leukocytes was sufficient for interferon induction. The interferon generated in human blood leukocytes was partially stable at pH 2.2; heating at 56 degrees C for 30 min reduced its activity 4-fold; antiserum to alpha-interferon inhibited it.
抗菌JRS疫苗被发现能够在人外周血白细胞和小鼠骨髓细胞中诱导干扰素产生。该疫苗在L-929细胞或人二倍体M-19细胞中不诱导产生干扰素。诱导后4-6小时内，培养液中出现干扰素，并在18-24小时达到最高水平。疫苗与白细胞接触1小时就足以诱导干扰素产生。人血白细胞中产生的干扰素在pH 2.2时部分稳定；56℃加热30分钟使其活性降低4倍；α-干扰素抗血清可抑制它。
