Adachi Shin-ichi, Endo Yuki, Mizushige Takafumi, Tsuzuki Satoshi, Matsumura Shigenobu, Inoue Kazuo, Fushiki Tohru
Laboratory of Nutrition Chemistry, Graduate School of Agriculture, Kyoto University.
Biosci Biotechnol Biochem. 2013;77(11):2175-80. doi: 10.1271/bbb.130234. Epub 2013 Nov 7.
Changes in the extracellular concentration of dopamine (DA) in the nucleus accumbens (NAc) shell and the basolateral amygdala (BLA) resulting from the voluntary ingestion of either corn oil, mineral oil, or 1% linoleic acid diluted with mineral oil as a vehicle were measured in rats by using in vivo microdialysis after they had been trained to establish a preference for corn oil. Ingesting the mineral oil caused no significant change in DA level in the NAc shell, whereas corn oil ingestion significantly increased the DA level during 0-15 min of the test session, reaching the maximum level of 129.8 ± 6.2% compared with the baseline after 10 min. Ingesting linoleic acid also resulted in a significant increase in DA level during 0-20 min, reaching 125.9 ± 9.0% after 10 min. Similar results were obtained in the BLA. Despite its very low calorie content, a low concentration of non-esterified fatty acid increased the DA levels equivalent to those resulting from corn oil in the brain's reward system.
在大鼠被训练建立对玉米油的偏好后，通过体内微透析测量了它们自愿摄入玉米油、矿物油或用矿物油作为载体稀释的1%亚油酸后，伏隔核（NAc）壳和基底外侧杏仁核（BLA）中多巴胺（DA）细胞外浓度的变化。摄入矿物油对NAc壳中的DA水平没有显著影响，而摄入玉米油在测试期间的0-15分钟内显著提高了DA水平，在10分钟后达到与基线相比129.8±6.2%的最高水平。摄入亚油酸在0-20分钟内也导致DA水平显著升高，10分钟后达到125.9±9.0%。在BLA中也获得了类似的结果。尽管其热量含量极低，但低浓度的非酯化脂肪酸在大脑奖励系统中提高了与玉米油相当的DA水平。
