Desantis V, Saltarella I, Lamanuzzi A, Mariggiò M A, Racanelli V, Vacca Angelo, Frassanito M A
Department of Biomedical Sciences and Human Oncology, Unit of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro Medical School, Bari, Italy.
Department of Biomedical Sciences and Human Oncology, Unit of General Pathology, University of Bari Aldo Moro Medical School, Bari, Italy.
Transl Oncol. 2018 Dec;11(6):1350-1357. doi: 10.1016/j.tranon.2018.08.014. Epub 2018 Sep 7.
Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. In physiological condition, autophagy funnels cytoplasmic constituents to autophagolysosomes for degradation and is an alternative way for cell-death behavior. Here, we inspected autophagy as a prosurvival mechanism essential for drug resistance in multiple myeloma (MM). Accordingly, autophagy inhibitors used in association to conventional anti-MM drugs might enforce the effect against resistant MM plasma cells and render autophagy a new therapeutic target.
自噬是一种细胞内自我降解过程，可平衡细胞能量来源并调节组织稳态。在生理条件下，自噬将细胞质成分输送到自噬溶酶体进行降解，是细胞死亡行为的一种替代方式。在此，我们研究了自噬作为多发性骨髓瘤（MM）耐药性所必需的一种促生存机制。因此，与传统抗MM药物联合使用的自噬抑制剂可能会增强对耐药MM浆细胞的作用，并使自噬成为一个新的治疗靶点。
