Greisen G
Acta Paediatr Scand. 1986 Jan;75(1):43-51. doi: 10.1111/j.1651-2227.1986.tb10155.x.
Forty-two preterm infants of 28-33 weeks of gestation were studied once during the first week of life by 133-Xenon clearance after intravenous injection to estimate global cerebral blood flow. Count rates detected over the chest were corrected for chest wall contribution and used as arterial input function. A neonatal blood-brain partition coefficient of Xenon was used for the calculation of a mean flow estimator (CBF-infinity). The technique was internally validated by use of differently obtained arterial input functions. In 11 infants without respiratory distress, CBF-infinity was 19.8 ml/100 g/min +/- 5.3 SD. In 24 infants treated with mechanical ventilation CBF-infinity was 11.8 ml/100 g/min +/- 3.2 SD. In 7 infants treated with continuous positive airway pressure CBF-infinity was 21.3 ml/100 g/min +/- 12.0 SD. When the reduction of CBF-infinity associated with mechanical ventilation was taken into account, the 9 infants with subependymal/intraventricular haemorrhage had increased CBF-infinity. The effects of gestational age, birthweight, mode of delivery, postnatal age, mean arterial blood pressure, PaCO2, blood haemoglobin and phenobarbitone medication were also analysed and found inconsistent. In conclusion, CBF was lower than expected and in infants requiring mechanical ventilation the values were lower still.
对42名孕28 - 33周的早产儿在出生后第一周内进行了一次研究，通过静脉注射133 - 氙清除法来估计全脑血流量。对胸部检测到的计数率进行胸壁贡献校正，并用作动脉输入函数。氙的新生儿血脑分配系数用于计算平均流量估计值（CBF-∞）。该技术通过使用不同获得的动脉输入函数进行了内部验证。在11名无呼吸窘迫的婴儿中，CBF-∞为19.8 ml/100 g/min±5.3标准差。在24名接受机械通气治疗的婴儿中，CBF-∞为11.8 ml/100 g/min±3.2标准差。在7名接受持续气道正压通气治疗的婴儿中，CBF-∞为21.3 ml/100 g/min±12.0标准差。当考虑到与机械通气相关的CBF-∞降低时，9名有室管膜下/脑室内出血的婴儿CBF-∞升高。还分析了胎龄、出生体重、分娩方式、出生后年龄、平均动脉血压、PaCO2、血红蛋白和苯巴比妥用药的影响，发现不一致。总之，CBF低于预期，在需要机械通气的婴儿中数值更低。
