实验室鱼类的毒理学病理学：两种鱼类和各种环境污染物的评估。
Toxicological pathology in laboratory fish: an evaluation with two species and various environmental contaminants.
机构信息
Laboratory for Pathology, National Institute of Public Health and Environmental Protection, PO Box 1, 3720 BA, Bilthoven, The Netherlands.
出版信息
Ecotoxicology. 1994 Mar;3(1):21-44. doi: 10.1007/BF00121386.
: This paper presents an overview of the studies carried out in small laboratory fish species to investigate the usefulness of histopathology as a tool in aquatic toxicology. The studies were performed with medaka (Oryzias latipes) and guppy (Poecilia reticulata) that were exposed to a variety of environmental contaminants for one and three months. Besides the measurement of routine toxicological parameters, total body histopathology was carried out. The data are summarized and evaluated in view of their contribution to the knowledge of toxicology, the specific responsiveness of animals and tissues, and the application in ecotoxicology. It is concluded that histopathology of (small) fish exposed to environmental contaminants may provide useful information as to target organs and mechanism of action: moreover, this technique can be more sensitive than routine parameters.
本文概述了在小型实验鱼类物种中进行的研究，以调查组织病理学作为水生毒理学工具的有用性。这些研究使用了斑马鱼（Oryzias latipes）和孔雀鱼（Poecilia reticulata），它们暴露在各种环境污染物中长达一个月和三个月。除了测量常规毒理学参数外，还进行了全身组织病理学检查。根据它们对毒理学知识的贡献、动物和组织的特定反应以及在生态毒理学中的应用，对数据进行了总结和评估。结论是，暴露于环境污染物的（小型）鱼类的组织病理学检查可能提供有关靶器官和作用机制的有用信息：此外，该技术比常规参数更敏感。
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