伊洛前列素（ZK 36374）对兔离体心脏缺血再灌注期间谷胱甘肽状态的影响。
Effects of iloprost (ZK 36374) on glutathione status during ischaemia and reperfusion of rabbit isolated hearts.
作者信息
Ferrari R, Cargnoni A, Curello S, Boffa G M, Ceconi C
机构信息
Cattedra di Cardiologia, Università di Brescia, Italy.
出版信息
Br J Pharmacol. 1989 Oct;98(2):678-84. doi: 10.1111/j.1476-5381.1989.tb12643.x.
Abstract
- Reperfusion of rabbit isolated hearts after 60 min of ischaemia resulted in poor recovery of mechanical function, release of creatine phosphokinase (CPK) and of reduced (GSH) and oxidized (GSSG) glutathione, reduction of mitochondrial superoxide dismutase (Mn SOD) activity and of tissue GSH/GSSG ratio with a shift of cellular thiol redox state toward oxidation, suggesting the occurrence of oxidative stress. 2. Pretreatment of the isolated heart with the stable prostacyclin analogue (iloprost) at 27 or 270 nM, but not at 2.7 nM, improved the functional recovery of the myocardium, reduced CPK, GSH and GSSG release, maintained Mn SOD activity and attenuated the occurrence of oxidative stress. 3. This effect of iloprost cannot be explained by a decreased demand or an enhanced delivery of oxygen during ischaemia or by a direct effect on glutathione peroxidase and reductase activity.
摘要
- 兔离体心脏缺血60分钟后再灌注，导致机械功能恢复不佳，肌酸磷酸激酶（CPK）、还原型（GSH）和氧化型（GSSG）谷胱甘肽释放，线粒体超氧化物歧化酶（Mn SOD）活性降低以及组织GSH/GSSG比值降低，细胞硫醇氧化还原状态向氧化方向转变，提示发生了氧化应激。2. 用27或270 nM而非2.7 nM的稳定前列环素类似物（伊洛前列素）预处理离体心脏，可改善心肌功能恢复，减少CPK、GSH和GSSG释放，维持Mn SOD活性并减轻氧化应激的发生。3. 伊洛前列素的这种作用不能用缺血期间需求降低或氧气输送增加来解释，也不能用对谷胱甘肽过氧化物酶和还原酶活性的直接作用来解释。
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