Centre for Endocrinology, Metabolism and Diabetes .
Gynecol Endocrinol. 2014 Jan;30(1):74-7. doi: 10.3109/09513590.2013.856408. Epub 2013 Nov 11.
The aim was to determine the prevalence of vitamin D insufficiency in pregnant immigrant women assessed by the levels of 25-hydroxyvitamin D, parathyroid hormone (PTH) and alkaline phosphatase (ALP) as well as the correlation to musculoskeletal pain. Sixty-eight pregnant immigrant women were included. Fifty-one native Swedish pregnant women served as controls. 25-hydroxyvitamin D, PTH, ALP and musculoskeletal pain, rated on a visual analogue scale, were analyzed in all women in gestational week 12 and in the immigrant women at 6-12 months postpartum. A significantly higher proportion of immigrant women (77.9%) had levels of 25-hydroxyvitamin D <25 nmol/l compared with 3.9% in controls. Of the immigrant women, 29.4% had 25-hydroxyvitamin D levels <12 nmol/l, but none of the controls. Musculoskeletal pain evaluated with a visual analogue scale (VAS) was significantly higher for the immigrant women than for the controls at gestational week 12. However, no within group correlation was seen between 25-hydroxyvitamin D levels, PTH or ALP and pain. A significant negative correlation between changes in 25-hydroxyvitamin D and pain from gestational week 12 to postpartum was observed. Hypovitaminosis D is prevalent in immigrant women living in Sweden. There is an indication that pain might be associated with hypovitaminosis D.
目的是通过检测 25-羟维生素 D、甲状旁腺激素（PTH）和碱性磷酸酶（ALP）水平，确定维生素 D 不足在接受评估的妊娠移民妇女中的流行率，并研究其与肌肉骨骼疼痛的相关性。共纳入 68 名妊娠移民妇女，51 名瑞典籍妊娠妇女作为对照组。对所有妇女在妊娠 12 周时以及移民妇女在产后 6-12 个月时进行 25-羟维生素 D、PTH、ALP 和肌肉骨骼疼痛（通过视觉模拟评分进行评估）的分析。与对照组（3.9%）相比，移民妇女（77.9%）25-羟维生素 D 水平<25nmol/L 的比例显著更高。在移民妇女中，29.4%的人 25-羟维生素 D 水平<12nmol/L，但对照组中没有人。与对照组相比，妊娠 12 周时移民妇女的肌肉骨骼疼痛（通过视觉模拟评分进行评估）显著更高。然而，在 25-羟维生素 D 水平、PTH 或 ALP 与疼痛之间未观察到组内相关性。在妊娠 12 周至产后期间，25-羟维生素 D 水平的变化与疼痛之间存在显著负相关。居住在瑞典的移民妇女中普遍存在维生素 D 不足。有迹象表明，疼痛可能与维生素 D 不足有关。
