Hetzel D J, Shearman D J
Br J Clin Pharmacol. 1984 Oct;18(4):587-90. doi: 10.1111/j.1365-2125.1984.tb02508.x.
We studied the effect of single 08.00 h doses of omeprazole or placebo on gastric acid secretion during the following night, 14 to 23 h after administration, in seven male subjects with duodenal ulcer. The drug was given orally, double-blind, in randomized order. Omeprazole 20 mg, 40 mg and 80 mg reduced mean total overnight acid output by 43%, 73% and 91% respectively and median pH increased from 1.4 with placebo to 1.6, 3.1 and 7.0 respectively. The inhibitory effect was maintained throughout the study period. No clinical side effects or abnormalities of laboratory screening tests were seen. Omeprazole is well tolerated and administration at 08.00 h produces prolonged dose related inhibition of acid output during the following night.
我们对7名患有十二指肠溃疡的男性受试者进行了研究，观察单次早上8点服用奥美拉唑或安慰剂对服药后当晚（给药后14至23小时）胃酸分泌的影响。药物通过口服方式给药，采用双盲、随机顺序。20毫克、40毫克和80毫克的奥美拉唑分别使夜间平均总酸分泌量降低了43%、73%和91%，pH值中位数从服用安慰剂时的1.4分别升至1.6、3.1和7.0。在整个研究期间，这种抑制作用一直保持。未观察到临床副作用或实验室筛查试验异常。奥美拉唑耐受性良好，早上8点给药可在随后的夜晚产生与剂量相关的、持续时间较长的酸分泌抑制作用。
