一种针对HLA - A11和A24的单克隆抗体。
A monoclonal antibody against HLA-A11 and A24.
作者信息
Foung S K, Taidi B, Ness D, Grumet F C
出版信息
Hum Immunol. 1986 Mar;15(3):316-9. doi: 10.1016/0198-8859(86)90006-6.
A monoclonal IgG antibody was produced from a mouse immunized with an A11, A24; B27, B44 Epstein-Barr virus transformed B lymphoblastoid cell line. The antibody, A11.1M, by standard lymphocytotoxicity assay, reacts with all cells expressing HLA-A11 and -A24. Absorption studies with both A11+, A24- and A11-, A24+ platelets removed antibody reactivity against A11 and A24 lymphocytes. The shared antigenic determinant between A11 and A24, as defined by this antibody, A11.1M, represents a new "supertypic" determinant.
用A11、A24；B27、B44型爱泼斯坦-巴尔病毒转化的B淋巴母细胞系免疫小鼠，产生了一种单克隆IgG抗体。通过标准淋巴细胞毒性试验，该抗体A11.1M与所有表达HLA - A11和 - A24的细胞发生反应。用A11阳性、A24阴性和A11阴性、A24阳性血小板进行吸收研究，消除了针对A11和A24淋巴细胞的抗体反应性。由该抗体A11.1M所定义的A11和A24之间的共同抗原决定簇代表一种新的“超型”决定簇。
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