College of Chemistry, Jilin University, Changchun 130012, PR China.
Talanta. 2013 Dec 15;117:203-8. doi: 10.1016/j.talanta.2013.08.051. Epub 2013 Sep 14.
In this paper, Au-Ag-Au double shell nanoparticles were prepared based on the reduction of the metal salts HAuCl4 and AgNO3 at the surface of seed particles. Due to the synergistic effect between Au and Ag, the hybrid nanoparticles are particularly stable and show excellent performances on the detection of 2-mercapto-1-methylimidazole (methimazole). The binding of target molecule at the surface of Au-Ag-Au double shell nanoparticles was demonstrated based on both localized surface plasmon resonance (LSPR) and surface-enhanced Raman scattering (SERS) spectra. The LSPR intensity is directly proportional to the methimazole concentration in the range of 0.10-3.00×10(-7) mol L(-1). The SERS spectrum can be applied in identification of methimazole molecule. The LSPR coupled with SERS based on the Au-Ag-Au double shell nanoparticles would be very attractive for the quantitative determination and qualitative analysis of the analytes in medicines.
本文采用种子生长法，通过还原氯金酸（HAuCl4）和硝酸银（AgNO3）金属盐在种子表面制备了 Au-Ag-Au 双壳纳米粒子。由于 Au 和 Ag 的协同作用，该混合纳米粒子特别稳定，在检测巯基-1-甲基咪唑（甲巯咪唑）方面表现出优异的性能。基于局域表面等离子体共振（LSPR）和表面增强拉曼散射（SERS）光谱，证明了目标分子在 Au-Ag-Au 双壳纳米粒子表面的结合。在 0.10-3.00×10(-7) mol L(-1) 范围内，LSPR 强度与甲巯咪唑浓度成正比。SERS 光谱可用于鉴定甲巯咪唑分子。基于 Au-Ag-Au 双壳纳米粒子的 LSPR 与 SERS 的结合，对于定量测定和定性分析药物中的分析物非常有吸引力。
