Dipartimento di Chimica, Biologia e Biotecnologie-Università di Perugia, via Elce di Sotto, 8, 06123 Perugia, Italy.
Molecules. 2020 Jul 28;25(15):3405. doi: 10.3390/molecules25153405.
Surface-enhanced Raman scattering (SERS) is a widely used technique for drug detection due to high sensitivity and molecular specificity. The applicability and selectivity of SERS in the detection of specific drug molecules can be improved by gathering information on the specific interactions occurring between the molecule and the metal surface. In this work, multilayer gold-silver bimetallic nanorods (Au@Ag@AuNRs) have been prepared and used as platforms for SERS detection of specific drugs (namely promethazine, piroxicam, furosemide and diclofenac). The analysis of SERS spectra provided accurate information on the molecular location upon binding and gave some insight into molecule-surface interactions and selectivity in drug detection through SERS.
表面增强拉曼散射（SERS）是一种广泛用于药物检测的技术，因为它具有高灵敏度和分子特异性。通过收集分子与金属表面之间发生的特定相互作用的信息，可以提高 SERS 在检测特定药物分子中的适用性和选择性。在这项工作中，制备了多层金-银双金属纳米棒（Au@Ag@AuNRs），并将其用作特定药物（即奋乃静、吡罗昔康、呋塞米和双氯芬酸）的 SERS 检测平台。SERS 光谱的分析提供了关于结合时分子位置的准确信息，并通过 SERS 对药物检测中的分子-表面相互作用和选择性提供了一些见解。
