全身 MRI 与骨骼闪烁显像用于检测骨转移瘤的比较：一项荟萃分析。
Comparison of whole-body MRI and skeletal scintigraphy for detection of bone metastatic tumors: a meta-analysis.
机构信息
Department of Medical Imaging, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
出版信息
Surg Oncol. 2013 Dec;22(4):261-6. doi: 10.1016/j.suronc.2013.10.004. Epub 2013 Oct 16.
PURPOSE
We performed a meta-analysis to investigate and compare diagnostic performance of whole-body MRI and skeletal scintigraphy for detection of bone metastatic tumors.
MATERIALS AND METHODS
PubMed and Embase were searched for relevant articles. We calculated sensitivities, specificities, diagnostic odds ratios (DOR), positive likelihood ratios (PLR), negative likelihood ratios (NLR), and constructed summary receiver operating characteristic curves using bivariate models for whole-body MRI and skeletal scintigraphy, respectively.
RESULTS
Across 7 studies (332 patients), whole-body MRI have similar patient-based sensitivity (0.84 vs 0.83), specificity (0.96 vs 0.94), DOR (137.0 vs 70.2), PLR (23.3 vs 13.0) and NLR (0.17 vs 0.19) with skeletal scintigraphy. Area under curves for whole-body MRI and skeletal scintigraphy was 0.94 and 0.89, respectively.
CONCLUSION
Both whole-body MRI and skeletal scintigraphy have good diagnostic performance for detecting bone metastatic tumors. It remains inconclusive whether whole-body MRI or bone scintigraphy is superior in detecting bone metastatic tumors.
目的
我们进行了一项荟萃分析，旨在调查和比较全身 MRI 和骨闪烁显像在检测骨转移瘤方面的诊断性能。
材料与方法
在 PubMed 和 Embase 中搜索相关文献。我们分别使用双变量模型计算了全身 MRI 和骨闪烁显像的敏感度、特异度、诊断比值比（DOR）、阳性似然比（PLR）、阴性似然比（NLR），并构建了汇总受试者工作特征曲线。
结果
在 7 项研究（332 例患者）中，全身 MRI 与骨闪烁显像具有相似的患者敏感度（0.84 对 0.83）、特异度（0.96 对 0.94）、DOR（137.0 对 70.2）、PLR（23.3 对 13.0）和 NLR（0.17 对 0.19）。全身 MRI 和骨闪烁显像的曲线下面积分别为 0.94 和 0.89。
结论
全身 MRI 和骨闪烁显像在检测骨转移瘤方面均具有良好的诊断性能。全身 MRI 或骨闪烁显像在检测骨转移瘤方面是否更优仍无定论。
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